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The transcription factor T-bet is best known to immunologists as a master regulator of T helper 1 cell differentiation. However, it is becoming apparent that T-bet has important functions in other leukocyte populations, including memory CD8+T cells, B cells, innate lymphoid cells, dendritic cells and natural killer cells. This Review discusses these emerging immunological roles for T-bet. Originally described over a decade ago as a T cell transcription factor regulating T helper 1 cell lineage commitment, T-bet is now recognized as having an important role in many cells of the adaptive and innate immune system. T-bet has a fundamental role in coordinating type 1 immune responses by controlling a network of genetic programmes that regulate the development of certain immune cells and the effector functions of others. Many of these transcriptional networks are conserved across innate and adaptive immune cells and these shared mechanisms highlight the biological functions that are regulated by T-bet.

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